Intravenous iron therapy

Intravenous Iron Therapy with Saccharated Iron Oxide

Intravenous iron therapy restores functional iron deficiency induced by infliximab.

BACKGROUND AND AIMS Infliximab (IFX) and iron sucrose (FeS) are of high value in inflammatory bowel disease (IBD). We aimed to assess the relative role of both therapies in IBD related anaemia and their safety when used in combination. METHODS IBD patients with anaemia receiving a first series of FeS infusions in addition to IFX were prospectively followed. We investigated serum kinetics of e...

Intravenous iron therapy: how far have we come?

Oral iron supplementation is usually the first choice for the treatment of iron deficiency anemia (IDA) because of its effectiveness and low cost. But unfortunately in many iron deficient conditions, oral iron is a less than the ideal treatment mainly because of adverse events related to the gastrointestinal tract as well as the long course required to treat anemia and replenish body iron store...

Making sense: a scientific approach to intravenous iron therapy.

More than 100 yr have passed since parenteral iron was first given to humans (1). Fifty yr ago, carbohydrate was first coupled to iron oxide (2), reducing the fierce toxicity of ferric iron and introducing the era of parenteral therapy with carbohydrate-iron agents (3,4). This is sufficient time to consider what we have learned about the risks and benefits of intravenous (IV) iron therapy; to r...

Ferumoxytol as an intravenous iron replacement therapy in hemodialysis patients.

BACKGROUND AND OBJECTIVES Intravenous iron is a key component of anemia management for chronic kidney disease (CKD). Ferumoxytol is a unique intravenous iron product that can be administered as a rapid injection in doses up to 510 mg. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This was a randomized, open-label, controlled, multicenter Phase 3 trial to evaluate the safety and efficacy of in...